Jonathon B. Cohen, MD, abettor professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, discusses the use of chimeric antigen receptor (CAR) T-cell analysis in patients with mantle corpuscle lymphoma (MCL).
CAR T-cell analysis is actuality explored as a analysis advantage for patients with relapsed/refractory MCL. Currently, the appearance II ZUMA-2 trial is evaluating the use of axicabtagene ciloleucel (axi-cel; Yescarta) in patients with relapsed/refractory MCL who no best acknowledge to treatment. Cohen says that at Winship Cancer Institute, patients with MCL enrolled on this balloon accept done actual well, which suggests that there is a abode for this analysis access in the MCL landscape.
Like added lymphoma subtypes, the claiming is award area CAR T-cell analysis fits into the analysis algorithm, Cohen says. In advancing lymphomas, it is easier to actuate this, he explains, because there are not abounding atypical therapies available to offer. For those patients who have progressed afterwards an autologous axis corpuscle displace or who are ineligible for transplant, CAR T-cell analysis can be a potential treatment option. However, he adds that there are several drugs accessible and in development for MCL that do not crave the accelerated analysis that CAR T-cell analysis does, says Cohen, authoritative the placement for this analysis alike added of a challenge.
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