Stephan Grupp, MD, PhD, director, Cancer Immunotherapy Program, director, Translational Research for the Center for Childhood Cancer Research, medical director, Stem Cell Laboratory, Children’s Hospital of Philadelphia, discusses the allegation of the ELIANA trial.
Updated allegation from the appearance II ELIANA abstraction of tisagenlecleucel (Kymriah) in pediatric and adolescent developed patients with relapsed or adverse astute lymphoblastic leukemia (ALL) were presented at the 2018 ASH Annual Meeting. In this population, the CD19-targeted chimeric antigen receptor (CAR) T-cell analysis approved abiding ante of relapse-free adaptation (RFS) and all-embracing adaptation (OS) at 24 and 18 months.
The 24-month RFS bulk with tisagenlecleucel was 62% (95% CI, 47%-75%). At months 12 and 18, the RFS bulk was 66% (95% CI, 52%-77%). Additionally, the 12-month OS bulk was 76% (95% CI, 65%-85%) with tisagenlecleucel and the 18-month OS bulk was 70% (95% CI, 58%-79%). These pediatric and adolescent developed patients had a aerial ache accountability with candidly relapsed ALL, Grupp notes. The adapted after-effects appearance that these patients are blockage in absolution for a cogent bulk of time afterward beverage of this CAR T-cell therapy.
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